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Abstract

October-December 2014 | Vol. 7 | Issue 4 | Page No 5-8
Current strategies for mapping the genes for Mendelian traits
Girisha KM
Department of Medical Genetics, Kasturba Medical College, Manipal University, Manipal-576104
Address for Correspondence Email: girish.katta@manipal.edu
 
Abstract
Mendelian traits or disorders refer to a group of phenotypes that exhibit one of the characteristic modes of inheritance: autosomal dominant, autosomal recessive and sex linked. These are also called ‘single gene disorders’ or ‘monogenic traits’ as it is usually a single gene that has a major effect on the phenotype. Though individually rare, as a group, there are more than 7,500 disorders known to be inherited in Mendelian fashion, and probably many more traits (normal variants) and so called private syndromes (affecting single families) exist. These are expected to affect about 5% of the general population. Hence they contribute to an important subgroup of human diseases and understanding them is important for any physician.
 
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